CLAVUCILL 50 mg - 40 mg amoxicillin / 10 mg clavulanic acid - 10 tablets (synulox) for DOG & CAT

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CLAVUCIL 50 MG

Active substances:

Amoxicillin (as amoxicillin trihydrate)

Clavulanic acid (as well as potassium clavulanate)

Excipients:

Erythrosine (E127) 0.05 mg.

Composition:
Clavucil 50 mg - 40 mg amoxicillin / 10 mg clavulanic acid,

INDICATIA (INDICATS)
Dogs and cats:

Treatment of infections caused by sensitive microorganisms at the combination of amoxicillin/clavulanic acid, in particular:

- Dermatitis (superficial and deep pyodermitis), caused by Staphylococcus

(pseudo)intermediums.

- Urinary tract infections caused by E. Coli.

- Respiratory tract infections caused by Streptococcus spp.

- Enteritis caused by E. coli.

Cats:

Treatment of infections caused by sensitive microorganisms at the combination of amoxicillin/clavulanic acid, in particular:

- Dermatitis (superficial and deep pyodermitis), caused by Staphylococcus

(pseudo)intermediums.

- Urinary tract infections caused by E. Coli

- Respiratory tract infections caused by Streptococcus spp.

- Enteritis caused by E. coli.

Contraindications

- Do not use in animals with known hypersensitivity to penicillin or other substances in the beta-lactamines group or to any of the excipients.

- It is not used in case of severe kidney dysfunction accompanied by anuria and oliguria.

-Do not use rabbits, guinea pigs, hamsters, chinchiles or gerbils.

ADVERSE REACTS

Gastrointestinal disorders (diarrhoea, vomiting) may occur after administration of the product. Treatment may be discontinued depending on the severity of the adverse effects and an assessment of the benefit/risk ratio by the veterinarian.

Very rarely allergic reactions can occur independently of the dose, such as reactions to the skin or even the anaphylactic sac. In these cases, therapy should be stopped immediately and symptomatic treatment is necessary.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals showing adverse reactions during treatment)

- frequent (more than 1, but less than 10 Take 100 animals)

- less common (more than 1, but less than 10 animals in 1000 animals)

- rare (more than 1 but less than 10 animals in 10000 animals)

- very rare (less than 1 animal in 10000 animals, including isolated reports).

If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

TINTA SPECIES

Dogs and cats.

POSOLOGY FOR EVERY SPECIA, CALE (CAL) OF ADMINISTRATION AND MODE OF ADMINISTRATION

Oral administration.

Quantities to be administered: The recommended dose is 10 mg amoxicillin/2.5 mg clavulanic acid/kg body weight ( = 12.5 mg of combined active substances) twice

per day, orally take dogs and cats, respectively 1 tablet/4 kg body weight Take every 12 h.

Body weight (kg) Number of tablets (twice/day)

(1.0 - 2.0) 1/2

1(2.1 - 4.0) 1

(4.1-6.0) 1 1/2

(6.1- 8.0) 2

> 8 Use 250 or 500 mg tablets

In the case of complicated infections, especially respiratory infections, a better cure rate is obtained by doubling the dose, respectively 25 mg of combination of active substances/kg body weight, twice a day.

Duration of treatment:

In most cases, 5 to 7 days of treatment is sufficient.
Chronic or refractory infections require a longer period of antibacterial treatment.
The duration of treatment is determined by the veterinarian, and must be long enough to ensure complete bacteriological healing.
To ensure proper dosing, body weight should be determined as accurately as possible to avoid under-dosing the product.

RECOMMENDATIONS ON CORRECT ADMINISTRATION
It is not used in case of known resistance in the combination of active substances.
Official, national and regional antimicrobial policies on the use of broad-spectrum antibiotics should be taken into account.
It is not used in sensitive bacteria with narrow-spectrum penicillins or amoxicillin as a single substance.
Whenever possible, the product should only be used on the basis of susceptibility tests.
Use of the product outside the instructions in the SPC may increase the prevalence of amoxicillin/clavulanic resistant bacteria and may decrease the effectiveness of treatment with 13-lactam antibiotics due to the potential for cross-resistance.
In animals with liver and/or kidney failure, the dosing regimen should be carefully evaluated.

ASTEPTING TIME

That's not the case.

SPECIAL PRECAUTIONS FOR DEPOSITION
Don't let the children's eyesight and skill go.
Do not keep at temperature above 25 oC.
Divided tablets should be kept in blisters. Any split portion of the unused tablet should be discarded after 24 hours.
Do not use this veterinary medicinal product after the expiry date marked on the blister and/or box.

SPECIAL ATTENTIONS
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Penicillins and cephalosporins can cause hypersensitivity reactions (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins can lead to cross-reactions to cephalosporins and vice versa.

Allergic reactions to these substances can occasionally be serious.
People with known hypersensitivity to penicillins should avoid contact with the veterinary medicinal product.
Handle this product carefully to avoid exposure, taking all recommended precautions.
If you develop symptoms as a result of exposure, such as a rash, seek medical advice immediately and present the product leaflet or label. Swelling of the face, lips or eyes or difficulty breathing are more serious symptoms and require urgent medical attention. Wash your hands after use.

Use during gestation or lactation:
Laboratory studies of rats and mice have produced no evidence of teratogenic or fetotoxic effects. No studies have been conducted on pregnant or lactating and cats. It is used only in accordance with the assessment of the benefit/risk ratio carried out by the veterinarian responsible.

Interactions with other medicinal products or other forms of interaction:
Chloramphenicol, macrolides, sulfonamides, tetracyclines may inhibit the antibacterial effect of penicillins. The allergic potential should also be taken into account following cross-reactions with other penicillins. Penicillins can increase the effect of aminoglycosides.

Overdose (symptoms. emergency procedures. antidote):
Following overdose of the product, mild gastrointestinal symptoms (diarrhoea, vomiting) may frequently occur.

Incompatibility: That's not the case.

SPECIAL PRECAUTIONS FOR THE ELIMINATION OF THE PRODUCT NOT USED OR DESOURS, AFTER CASE
Medicines should not be disposed of in waste water or household waste.
Ask your veterinarian for information on how to dispose of medicines that are no longer needed. These measures contribute to environmental protection.

It is released only on the basis of a veterinary prescription.

Packaging presentation: boxes with 10, 100 or 500 tablets.
Not all pack sizes can be marketed.